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The most serious adverse reaction to contrast agents is anaphylactic shock, which must be treated as an emergency. this type of hypersensitivity reaction, the contrast agent causes the release of histamine from mast cells and basophils.
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If a drug is water soluble it is likely to remain in the blood stream and its volume of distribution will be relatively small and equal blood volume.
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Tetracyclines accumulate in tooth enamel and bone and are not recommended for use in children because they cause discolouration of the teeth and stunt bone growth.
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