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Official bodies concerned with the use, quality and safety of medicines are the Commission on Human Medicines, the Medicines and Healthcare Products Regulatory Agency and the National Institute for Health and Clinical Excellence. Patient compliance is important for successful drug therapy. Compliance in this context is defined as the extent to which the patient follows the clinical prescription. Non-compliance and reasons why patients do not always take drugs as prescribed should be appreciated. Some common reasons for non-compliance are that the patient has doubts about a drugs effectiveness, they believe they are cured, they misunderstand instructions, dosage regimes are too complicated, or they experience unacceptable side effects.

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Distribution can also be affected due to differences in body composition and the availability of plasma proteins for binding. At these extremes of life, buys zolpidem online pharmacy tend to produce greater and more prolonged effects. Many disease states can cause individual variation in response to drugs. Any disease that results in alteration in the pharmacokinetics of a drug will create these variations.

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